Psilocybin Mushrooms

Used ceremonially for thousands of years across Mesoamerican cultures, psilocybin mushrooms produce profound alterations in perception and cognition. Clinical trials at Johns Hopkins and NYU have shown significant promise in treating depression, addiction, and end-of-life anxiety. Ann Arbor decriminalized natural psychedelics in 2020.

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DMT

N,N-Dimethyltryptamine is an endogenous tryptamine found in many plants and animals. Known for intensely brief visionary states, it is the active component in ayahuasca when combined with an MAOI. Ongoing research explores its role in consciousness, near-death experience, and neuroplasticity.

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5-MeO-DMT

Found in the Sonoran Desert toad and several plant species, 5-methoxy-DMT produces one of the most powerful non-ordinary states known — often described as ego dissolution. Emerging research suggests rapid and lasting reductions in anxiety, depression, and PTSD symptomology.

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Mescaline

Derived from peyote, San Pedro, and other cacti, mescaline has been central to Indigenous spiritual practice for over 5,000 years. Its long-duration phenethylamine experience is characterized by vivid color enhancement, empathic depth, and introspective clarity. Research into its therapeutic applications is ongoing.

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SR 17018

SR 17018 is a biased mu-opioid receptor agonist that produces analgesia without euphoria or respiratory depression. Unlike conventional opioids, it does not build tolerance — and preclinical research shows it actively reverses existing opioid tolerance while suppressing withdrawal symptoms. It has emerged in harm reduction communities as a tool for opioid cessation: allowing people to stop fentanyl, heroin, and other opioids without acute withdrawal, while walking their tolerance back to baseline.

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Managing a Drug Crisis

A practical harm reduction guide for sitters, friends, and bystanders. Covers crisis assessment, life-threatening response, psychological and spiritual crisis support, naloxone use, Michigan medical amnesty, drug waste disposal, syringe handling, and post-crisis integration.

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